De Leidsche Flesch Symposium
Sneak peak of the week!
Every week we will place another abstract in this mail, so keep reading if you are interested!
On March 25th De Leidsche Flesch organises a grand symposium on the subject 'life'. Speakers from all over the Netherlands will talk about life from a fundamental perspective. Want to know more? Go to our website!
Organ transplantations and the immune system
“The field is continuously fascinating. In fact, I’ve often thought a good title for either a book or a lecture about immunology would be Endless Fascination” – Dr William Erwin Paul (2012)
The immune system of plants and animals is very complex and we are still in the very beginning of understanding this complexity. Every small step we take in this direction leaves us once more fascinated with the efficiency, and preciseness of the system. In my lecture I will first explain what is often known as the main function of the immune system: discriminating self (harmless) from non-self (dangerous). The immune system has several mechanisms to stay tolerant to healthy cells of the host (self) while mounting very efficient immune responses to foreign pathogens. During an organ transplantation self/non-self discrimination plays a very important role. Though it is meant to be harmless, a donor organ is seen as a foreign invasion to the host body. I will summarize the computational tools we developed to predict the "foreigness" of a solid organ transplantation.